Microvascular and macrovascular disease cause considerable mortality and morbidity both among patients with non—insulin-dependent diabetes mellitus and those with insulin-dependent diabetes mellitus. Furthermore, non—insulin-dependent and insulin-dependent diabetes mellitus overlap in their pathogenesis as well as shortand long-term complications. In the diabetic patient, genetic susceptibility as well as other factors, ie, microalbuminuria, hypertension, high protein intake, blood glucose control, etc, ultimately culminate in a diffuse disease process, eg, diabetic vascular and/or renal disease. Early predictors of susceptibility for development of renal disease in diabetic subjects would help focus our treatment strategies. The role of microalbuminuria as a prognostic marker for the major complications of insulin-dependent diabetes mellitus has been previously reviewed. We reviewed the role of microalbuminuria as a prognostic marker for progression of diabetic renal disease in subjects with non—insulin-dependent diabetes mellitus. We examined treatment strategies to lower microalbuminuria and its associated impact on disease progression.
(Arch Intern Med. 1994;154:146-153)
Abbott KC, Sanders LR, Bakris GL. Microalbuminuria in Non—Insulin-Dependent Diabetes Mellitus: Implications for Renal Survival. Arch Intern Med. 1994;154(2):146–153. doi:10.1001/archinte.1994.00420020048006
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