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February 28, 1994

Aspirin, NSAIDs, and Risk Reduction of Colorectal Cancer: The Problem Is Translation

Author Affiliations

Oncology Consultants 199 W.H. Taft Rd, Ste 101 Cincinnati, OH 45219; Departments of Internal Medicine and Pharmacology University of Michigan Medical School Medical Service Veterans Affairs Medical Center Ann Arbor, MI 48109

Arch Intern Med. 1994;154(4):366-368. doi:10.1001/archinte.1994.00420040014002

CANCERS OF the colon and rectum cumulatively account for approximately 15% of all visceral tumors, affecting about one person in 20 in the United States and most other Western countries. Rapid advances in molecular biology may soon allow for genetic screening of individuals at risk for the development of colorectal cancer. The gene for familial adenomatous polyposis has been cloned and sequenced, and recently the gene coding for hereditary nonpolyposis colorectal cancer has been mapped to a locus on chromosome 2.1 Familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer may account for as much as 5% to 14% of all colorectal cancer in industrialized nations, but men and women over the age of 40 years still constitute the the largest population at risk.

During the last several decades, the incidence of these cancers has remained relatively constant, although there has been a progressive trend toward disease of the more

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