[Skip to Navigation]
May 9, 1994

Syphilis Presenting as the 'Blue Toe Syndrome'

Author Affiliations

From the Departments of Internal Medicine (Drs Federman and Valdivia) and Dermatology and Cutaneous Surgery (Dr Kirsner), University of Miami (Fla) School of Medicine and Miami Veterans Hospital. Dr Federman is now with the Department of Medicine, Veterans Affairs Medical Center, West Haven, Conn.

Arch Intern Med. 1994;154(9):1029-1031. doi:10.1001/archinte.1994.00420090121013

The abrupt development of cyanotic and painful toes, "the blue toe syndrome," has been attributed to a number of medical conditions. We describe a patient in which the workup for this condition failed to elucidate a typical cause. Skin biopsy, serologic findings, and response to treatment led to the diagnosis of secondary syphilis. Our experience indicates that secondary syphilis should be included in the differential diagnosis of patients presenting with the blue toe syndrome.

(Arch Intern Med. 1994;154:1029-1031)

Add or change institution