I have read with interest the article by Arav-Boger et al1 on single-dose vs multiple-day antibacterial treatment of acute urinary tract infections (UTIs) in women.
Based on our recent comparative study on the effect of a single-dose of ofloxacin (400 mg), norfloxacin (800 mg), or ciprofloxacin (500 mg) in 174 acute UTIs in premenopausal and postmenopausal women,2 we agree with the authors' statements that the efficacy of single-dose treatment is similar in patients with low and high urinary bacterial counts and that multiple-day treatment with norfloxacin is probably more effective than single-dose treatment in UTI in women.
We disagree, however, with the authors' generalization that "single-dose treatment of uncomplicated UTI in women is less effective than multiple-day treatment," a statement that should be reserved for norfloxacin. Our study clearly demonstrated that single-dose treatment with ofloxacin or ciprofloxacin cured 97% of the uncomplicated UTIs in women and, thus, proved
Pfau A. Urinary Tract Infections With Low and High Colony Counts in Young Women: Spontaneous Remission and Single-Dose vs Multiple-Day Treatment. Arch Intern Med. 1994;154(21):2501–2502. doi:10.1001/archinte.1994.00420210141018
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