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September 11, 1995

Pamidronate Treatment of the Neurologic Sequelae of Pagetic Spinal Stenosis

Author Affiliations

From the Department of Medicine, University of Auckland (New Zealand).

Arch Intern Med. 1995;155(16):1813-1815. doi:10.1001/archinte.1995.00430160167017

Spinal stenosis is a serious complication of Paget's disease of bone. Surgical decompression has a high complication rate and is not always effective. Medical therapy with bisphosphonates is established treatment in other forms of Paget's disease. To our knowledge, this is the first report of the use of intravenous pamidronate disodium as the sole treatment of lower limb weakness attributable to pagetic spinal stenosis. Our patient has been restored to independent living and has maintained his remission, with repeated treatment, for more than 5 years.

(Arch Intern Med. 1995;155:1813-1815)