Rhinocerebral mucormycosis with intracranial involvement has a high mortality. The standard therapy consists of aggressive surgical débridement accompanied by high doses of amphotericin B deoxycholate. Even with this therapy, the mortality rate has been 48% in the series reported since 1980. We treated a 60-year-old diabetic woman with rhinocerebral mucormycosis involving the cavernous sinus whose infection responded to medical therapy with amphotericin B lipid complex. To our knowledge, this is the only well-documented medical cure of a patient with rhinocerebral mucormycosis and intracranial involvement.
(Arch Intern Med. 1996;156:337-339)
Strasser MD, Kennedy RJ, Adam RD. Rhinocerebral Mucormycosis: Therapy With Amphotericin B Lipid Complex. Arch Intern Med. 1996;156(3):337–339. doi:10.1001/archinte.1996.00440030145018
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