I am grateful to the correspondents for their interest in my review.
McMahon reports the development of restless legs syndrome (RLS) coincident with the resolution of ankle edema. I have heard similar reports from women in whom RLS developed during pregnancy. The period of leg elevation and rest necessitated by the edema may account for the association between these events rather than any specific pathophysiological link.
In my review, I focused on those therapies that have been evaluated in controlled trials. Most patients who come to the attention of physicians will have tried and failed to benefit from standard analgesics. However, it seems reasonable to try simple analgesics, as Hindmarsh notes, in people with mild and infrequent symptoms.
Neustadt suggests the use of ophenadrine citrate in patients with RLS. I have no personal experience with this agent. However, although Popkin1 reported good results with ophenadrine citrate in an open
O'Keeffe ST. Restless Legs Syndrome-Reply. Arch Intern Med. 1996;156(20):2390. doi:10.1001/archinte.1996.00440190148019
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