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February 24, 1997

Association of Sarcoidosis, Insulin-Dependent Diabetes Mellitus, and Ulcerative Colitis

Author Affiliations

Osaka and Kyoto, Japan

Arch Intern Med. 1997;157(4):465-467. doi:10.1001/archinte.1997.00440250125022

Sarcoidosis is known to be related to autoimmune disorders. A high frequency of endocrine autoimmunity, especially autoimmune thyroid disease, was reported recently in a study of Swedish patients with sarcoidosis.1 Insulin-dependent diabetes mellitus (IDDM) is rarely found in patients with sarcoidosis, and, to our knowledge, there are only 2 reports2,3 of sarcoidosis coexisting with polyglandular autoimmune syndrome and celiac disease. To our knowledge, the association of sarcoidosis with IDDM and ulcerative colitis has not been previously reported. We recently treated a Japanese patient with sarcoidosis who presented with such an unusual association.

Report of a Case.  A 22-year-old man was admitted to our hospital because of diabetic ketoacidosis in December 1992. Since the age of 20 years, he had been affected by ulcerative colitis, which was diagnosed on radiographic findings and histological evidence. On admission, the findings of his physical examination were unremarkable. Diabetic ketoacidosis (arterial blood gas

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