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April 28, 1997

Pharmacological Regulation of Blood Glucose Levels in Non—Insulin-Department Diabetes Mellitus

Author Affiliations

From the Departments of Medicine and Pharmacology, University of Arizona Health Sciences Center, Tucson.

Arch Intern Med. 1997;157(8):836-848. doi:10.1001/archinte.1997.00440290014001

Non—insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non—insulin-dependent diabetes mellitus.

Arch Intern Med. 1997;157:836-848