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Editor's Correspondence
March 12, 2001

Multivitamin Supplements Are Effective and Inexpensive Agents to Lower Homocysteine Levels—Reply

Arch Intern Med. 2001;161(5):771-778. doi:

In reply

We thank Mr Vos for his interest in our manuscript. In his comments, Mr Vos argues that "it is time to recommend an over-the-counter multivitamin to anyone at risk for cardiovascular conditions." We are unconvinced that existing data justify a general recommendation of this kind. Indeed, our own data suggest that in patients with unstable coronary syndromes, only a homocysteine level greater than the upper normal level is associated with increased risk of premature death.1

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