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Comments, Opinions, and Brief Case Reports
April 9, 2001

Pituitary Gangliocytoma-Adenoma Presenting With Acromegaly: Response to Treatment

Arch Intern Med. 2001;161(7):1010-1011. doi:

Acromegaly is the clinical syndrome that results from excessive secretion of growth hormone (GH). The most common cause of acromegaly is a somatotroph (GH-secreting) adenoma of the anterior pituitary gland. In rare cases, overproduction of GH-releasing hormone (GHRH) by functional hypothalamic tumors such as hamartomas and gangliocytomas may cause acromegaly by inducing proliferation of GH-secreting pituitary cells.1 However, to our knowledge, few cases of combined pituitary adenoma and sellar gangliocytoma presenting with acromegaly have been reported.2

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