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Editor's Correspondence
May 14, 2001

Baseline Rates of Disease May Account for Some Arrhythmia Risk—Reply

Arch Intern Med. 2001;161(9):1235. doi:

In reply

We appreciate the valuable comments of Dr Williams. Confounding by indication is a potential source of bias in observational studies. The overrepresentation of patients with pulmonary disease in a study may increase susceptibility for cardiac arrhythmias found in the results. In our study we attempted to adjust for the severity of pulmonary disease by including the use of any corticosteroid and previous hospitalizations for pulmonary disease in the multiple regression analysis.1

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