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September 1958


AMA Arch Intern Med. 1958;102(3):450-458. doi:10.1001/archinte.1958.00030010450017

By 1956 the total number of reported cases of cryptococcosis was over 300,1-5 and the total has been added to since. It seems reasonable to assume that there may be many other unreported cases, or cases in which Cryptococcus is the likeliest etiology but could not be proved.

The commonest type of infection is of the central nervous system, but cases have been reported of primary cryptococcosis in the skin2 and one case of visceral cryptococcosis that presented a clinical picture of granulocytic leukemia3 before death. There are four reports of Cryptococcus infection of the eye, all made postmortem.4-8 Cryptococcosis has also been found to be responsible for cases of adrenal insufficiency, coexistent with Hodgkin's disease, tuberculosis, and histoplasmosis, in which cases the clinical findings were of a rather bizarre nature. The clinically confused picture often found has led to the declaration that "perhaps it can be postulated that any