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This well-written and richly illustrated book emphasizes, as indicated in the subtitle, correlation
of changes in plasma proteins with disease states. Primary attention is given to paper
electrophoresis as method of analysis, in combination with turbidity and flocculation reactions
In the preface, the authors explain that space restrictions preclude discussion of the closely
related problems of the hemoglobins, coagulation, and lipoproteins to a significant extent.
Chapters on paper chromatography and spectrophotometry which had been part of the previous
(second, 1951) edition were omitted from the new book because, on the one hand, the authors
found that analysis of serum proteins by serologic methods, including immunoelectrophoresis,
was, in part, replacing those methods; on the other hand, the latter were well covered in
recently published handbooks. No explanation is given for the almost complete lack of attention
to circulating enzymes, which are assuming an increasingly prominent role in physiologic
Mandel EE. Books. AMA Arch Intern Med. 1958;102(3):511–513. doi:10.1001/archinte.1958.00030010511035
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