The development of pulmonary lesions during the course of
Hodgkin's disease (HD) represents a diagnostic problem. Invasive studies are usually necessary to differentiate pulmonary
parenchymal involvement with HD from infectious complications. A retrospective review has revealed five cases in which
sputum cytodiagnosis of HD involving the lung was made. All
cases were confirmed by either histopathologic examination or
response to therapy. The cytology reveals a polymorphic picture
with a large number of lymphoid mononuclear cells, macrophages, and unclassified cells. These cells usually have single
nuclei that are lobulated and contain prominent nucleoli. Occasionally, classic Reed-Sternberg cells are present. Such evidence makes the specimen diagnostic of HD. This experience
suggests that sputum cytodiagnosis may be a useful adjunctive
diagnostic tool in the evaluation of the conditions of patients with
HD and pulmonary lesions and may make more invasive diagnostic procedures unnecessary.
(Arch Intern Med 140:910-913, 1980)
Giangreco A, Ettinger DS, Dragon LH, Gupta PK, Lenhard RE. Sputum Cytologic Diagnosis of Hodgkin's Disease Involving the Lung. Arch Intern Med. 1980;140(7):910–913. doi:10.1001/archinte.1980.00040020910007
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