[Skip to Navigation]
July 1980

Fibrinogen I 125 Leg Scanning

Arch Intern Med. 1980;140(7):987. doi:10.1001/archinte.1980.00040020987029

To the Editor.—  The technique of measurement and the method of data analysis for fibrinogen I 125 scanning of the lower limbs markedly influences the incidence of "positive" scans (detection of thrombus). In a detailed analysis of the technique, Roberts1 has strongly crticized previous published reports on the basis of a number of technical errors and the differing end points taken as a "positive" scan. He has pleaded for standardization of technique and analysis, and some recent studies have adopted this procedure.2,3With respect to the article by Sautter et al in the Archives (139:148-153, 1979), the following points are of particular note:1. There is a need for more than one precordial measurement during each scan, to allow for positional errors in the setting of the reference value (these errors can be considerable).2. A correction factor must be applied to all readings to allow for daily variations in background radiation.3. Postoperative, rather than

Add or change institution