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Article
February 1908

A CONTRIBUTION TO OUR KNOWLEDGE OF THE ACETONE BODIES.WITH A CLINICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF DIACETIC ACID AND ACETONE.

Arch Intern Med (Chic). 1908;I(II):218-230. doi:10.1001/archinte.1908.00050020083004
Abstract

The scientific and clinical importance of acetone bodies, viz. : acetone, diacetic and oxybutyric acids, is demonstrated by the many investigations which have been made regarding them in the last decade. As evidences of disordered metabolism they are of significant value. The Germans have been the leaders in this promising field of research, but many valuable studies have come from our own countrymen, among which may be recalled the work of Herter, Joslin, Brewer, Baldwin, Hubbard, Brackett, Stone, Low and others.

While much of the earlier work led to conclusions more or less contradictory, the more recent observations permit us to -coordinate our knowledge and are full of promise for a rational system of prophylaxis and therapy. It seems worth while, therefore, to review some of the facts as we know them to-day.

THE RELATION OF THE ACETONE BODIES TO ONE ANOTHER.  The relationship of the acetone bodies is a result

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