The appearance of the work of Wassermann, Neisser and Bruck,1 and of Wassermann, Neisser, Bruck and Schucht2 describing a positive serum reaction in syphilis by means of Wassermann's modifications of the Bordet-Gengou method of complement binding, gave an impetus to the study of serum reactions in syphilis, paresis and tabes, and of the diagnostic value of the results obtained. The reaction of Wassermann, Neisser and Bruck is based in principle on the specific binding of complement, such as occurs, for instance, in the presence of an immune precipitin containing serum and the corresponding precipitinogen. In the reaction the antigen is represented by an extract of the liver of a syphilitic fetus, and the antibody is contained in the blood serum of a syphilitic patient or in either the blood serum or cerebrospinal fluid, or both, of a paretic or tabetic patient.
To carry out a test for the
WOLLSTEIN M, LAMAR RV. THE PRESENCE OF ANTAGONISTIC SUBSTANCES IN THE BLOOD SERUM IN EARLY AND LATE SYPHILIS AND IN PARESIS AND TABES. Arch Intern Med (Chic). 1908;I(III):314–319. doi:10.1001/archinte.1908.00010010042004
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