To Frölich1 of Breslau belongs the credit of having first called attention to the blood in pertussis. During an epidemic of this disease in the summer of 1897, he examined the blood in fifty-five cases, making total leucocyte counts in all the cases and differential counts in fifteen. In one case he made three counts during three consecutive weeks and in another two counts; in all the other cases the patients were examined but once.Summarizing his results, he says, in conclusion, that in this disease there is a constant leucocytosis and lymphocytosis which in individual cases may show high values. The highest counts were noted when the number and severity of the coughing spells reached their maximum, and with the disappearance of these the leucocytosis disappeared. He considered, however, that the blood examination would be of no great value because the changes can not be shown early enough in
BARACH JH. MORPHOLOGY OF THE BLOOD IN PERTUSSIS. Arch Intern Med (Chic). 1908;I(VI):602–614. doi:10.1001/archinte.1908.00050050033003
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