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Article
January 1909

THE INTESTINAL LESIONS CAUSED BY TRICHINELLA SPIRALIS IN RATS.

Author Affiliations

BOSTON

From the Laboratory of the Department of the Theory and Practice of Physic, Harvard University.

Arch Intern Med (Chic). 1909;II(6):505-516. doi:10.1001/archinte.1909.00050110002001
Abstract

In a former publication1 the lesions caused by Trichinella spiralis in man were described. The interstitial lesions in this case were not preserved on account of postmortem changes. The object of this work has been to study the intestinal lesions caused by the Trichinella spiralis and the mode of entrance of the embryos. As human tissue was not available, white rats were used.

Askanazy,2 working with rabbits, described the following intestinal lesions : metamorphosis of cylinder cells to beaker cells, desquamation of the epithelial cells in rows, superficial necrosis of the points of the villi with hemorrhage, destruction of the glandular structure with invasion by leucocytes, and dilatation of the lymph spaces which are filled with a fine granular material. He asserts that an adult female, after winding herself about a villus, pierces the epithelium and connective tissue and finally penetrates into the central lymph space of the

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