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Article
February 1909

METABOLISM IN DIABETES.

Arch Intern Med (Chic). 1909;III(1):1-22. doi:10.1001/archinte.1909.00050120004001
Abstract

In my student days in Germany during the winter semester of 1898, I visited the laboratory of the botanical garden of Munich to call on Oscar Loew, who had some time before been assistant to Dr. R. Ogden Doremus in the City College of New York. Loew showed me how he was passing the vapor of methyl-alcohol (CH3CH) over hot oxidized wire gauze and collecting a product in water which was formaldehyd (CH2O). This he shook with milk of lime and obtained, after further treatment, a syrup which was as sweet as sugar and which represented the condensation of six molecules of formaldehyd into one of sugar. This artificially prepared syrup gave many reactions for sugar, but did not rotate polarized light nor was Loew able to crystallize it. At the time I had been preparing levulose in Voit's Munich laboratory. I told Loew of the

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