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February 1909


Author Affiliations


From the Laboratory of Experimental Pathology, University of Pennsylvania.

Arch Intern Med (Chic). 1909;III(1):78-91. doi:10.1001/archinte.1909.00050120093005

During the course of our experiments regarding the influence of various substances and conditions on the production of edema it was deemed advisable to use some animals in which there was a heart lesion in order to note the effect of chronic myocarditic lesions on the production of ascites, intestinal fluid and urine.

Experimental lesions of the myocardium have been produced and described by a number of observers. Ribbert,1 by injecting intravenously cultures of Staphylococcus pyogenes aureus into rabbits, was able to produce both endocardial and myocardial lesions, the latter consisting of a central necrotic area surrounded by a wall of polynuclear leucocytes; none of the animals treated in this manner survived the injection for any great length of time. Zwaschkewitsch2 found that the hearts of animals exposed to high temperatures for a considerable period of time showed a cloudy swelling of the muscle fibers; Litten,

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