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Article
March 1909

THE AGGLUTINATING POWER OF THE BLOOD SERUM OF TUBERCULOUS PATIENTS: SERUM DIAGNOSIS—SERUM PROGNOSIS

Author Affiliations

LYONS, FRANCE

Arch Intern Med (Chic). 1909;III(2):125-138. doi:10.1001/archinte.1909.00050130036003
Abstract

The serum diagnosis of tuberculosis is to-day one of the most generally employed and most reliable laboratory methods of diagnosis.

1.—HISTORICAL  It is well known that the ordinary cultures of the bacillus of Koch can not be used for agglutination. Arloing, however, in 1898,1 obtained a fluid homogeneous culture of the tubercle bacillus and demonstrated its specific agglutinability by the serum of tuberculous human beings or animals, thus rendering possible the serum diagnosis of tuberculosis. Arloing and Paul Courmont2 later perfected the method, determining the best manner of producing homogeneous cultures, applying the serum diagnosis to hundreds of patients and studying in these and on animals which had been rendered tuberculous the agglutinating power of the blood. Paul Courmont has further studied3 local serum diagnosis (diagnosis of the nature of pathological serous fluids by their agglutinating power) and the serum prognosis of pleurisies. To-day the Lyonese

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