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June 1909

A REPORT ON THE EXPERIMENTAL PRODUCTION OF CHRONIC NEPHRITIS IN ANIMALS BY THE USE OF URANIUM NITRATE.

Arch Intern Med (Chic). 1909;III(5):375-410. doi:10.1001/archinte.1909.00050160004001
Abstract

INTRODUCTION.  The study of chronic nephritis is one which for many years has commanded the interest and investigation of many observers. Since 1827, when Richard Bright first described the condition which we now know as Bright's disease, many attempts have been made to determine the relationship existing between the various types of diseases of the kidney, and the conditions which influence the development of those different types. It is impossible to discuss here the immense amount of literature which has been written on this subject, or to consider the bitter controversies which have waged. Even to-day, although certain types of subacute and chronic conditions are universally recognized, there is great difference of opinion as to the etiologic factors at work in the development of each.In 1879 Weigert1 published an elaborate discussion of kidney diseases viewed from the standpoint of pathologic anatomy, and in his classification he described a

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