Although Addison's disease is one very closely connected with a gland which must have important functions regulating metabolism, since associated with tuberculosis of this organ are general weakness, loss in weight and a marked pigmentation of the skin and the mucous membranes, nevertheless the amount of chemical work which has been done in an attempt to throw light on the process is not large.
Those investigators who have taken up the cases from the point of view of protein metabolism have in the main contented themselves with a study of the nitrogen balance, and these observations have been extended further to a simultaneous determination of the effect of the administration of adrenal gland substance on the protein breakdown.
Even here the results are not uniform, for Senator1 believes that the physiologic effect of the gland substance in case of Addison's disease is to lead to increase in body
WOLF CGL, THACHER HC. PROTEIN METABOLISM IN ADDISON'S DISEASE. Arch Intern Med (Chic). 1909;III(5):438–445. doi:10.1001/archinte.1909.00050160067004
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