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Article
June 1909

THE DIAGNOSTIC VALUE OF HEMOLYSIS IN CASES OF CANCER

Arch Intern Med (Chic). 1909;III(5):467-473. doi:10.1001/archinte.1909.00050160100007
Abstract

Recent researches on various biologic properties of the blood in cases of cancer have given hope that a diagnostic blood test could be found. Of these studies none at first seemed more promising than those which dealt with the hemolytic properties of the blood serum.

Within the last year the statements of Crile have aroused much expectation. Crile found the occurrence of isohemolytic serum so very frequent (80 to 100 per cent. of the cases) in carcinoma, and so very rare in other diseases, that from his work there seemed little doubt that the hemolytic reaction would be exceedingly valuable in diagnosis. Other workers, however, have not confirmed his findings, and the whole question as to the value of this method required re-examination.

With the aid of a modified technic, the chief advantage of which is that it enables us to perform a large number of tests readily with a

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