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June 1909


Author Affiliations


Arch Intern Med (Chic). 1909;III(5):519-568. doi:10.1001/archinte.1909.00050160152012

Anaphylaxis (ana, against, and phylax, guard, or phylaxis, protection), also called hypersusceptibility, supersensitiveness, is a condition of unusual or exaggerated susceptibility of the organism to foreign substances. The word "anaphylaxis" was introduced by Richet to describe a contrary condition to prophylaxis. As we now regard the phenomenon, the word is a misnomer, for we look upon the condition of hypersusceptibility as a distinct benefit and advantage to the organism. In fact, protection against a large class of infections depends on an altered power of reaction, i. e., hypersusceptibility or anaphylaxis.

This state may be congenital or acquired, and is specific in nature. The condition of anaphylaxis may be brought about by the introduction of any strange protein into the body. Hypersusceptibility to proteins that are non-poisonous in themselves may readily be induced in certain animals.

An animal may be in a condition of hypersusceptibility and

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