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Article
July 1909

SOME PROBLEMS IN IMMUNITY AND THE TREATMENT OF INFECTIOUS DISEASES

Arch Intern Med (Chic). 1909;IV(1):32-63. doi:10.1001/archinte.1909.00050170037004
Abstract

SOME FUNDAMENTAL FACTORS OF PATHOGENICITY AND INFECTIOUSNESS  If the animal body and the bacteria were absolutely fixed in their physiologic characters, varying in these neither qualitatively nor quantitatively in the adaptive sense when brought into contact with each other, it would probably be a much simpler matter than it is, to determine by careful study and experiment the exact factors underlying the conditions of pathogenicity and infectiousness of micro-organisms, and the reasons for the weakness or strength of the body when invaded by them, and we might thus, from a knowledge of the physiology of any given animal and bacterium, prognosticate the result of their activities, the one on the other. While this, of course, is not the case, still there are certain more or less fundamental requirements which experience has taught us must be met by an organism to be infectious for any given animal, and by infec

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