On Dec. 10, 1908, Dr. Randle C. Rosenberger of the Jefferson Medical College, Philadelphia, Pa., read a paper before the Philadelphia Pathological Society on the occurrence of tubercle bacilli in the circulating blood. The paper was afterward published in The American Journal of Medical Sciences for February, 1909. In this paper he recorded that he had made microscopic examinations of the blood of 125 tuberculous individuals, some of whom were affected with only incipient tuberculosis, and that he had found tubercle bacilli in the blood of every one of these individuals. In some cases only a few bacilli were seen, bur, to use his own words, "they were mostly in large numbers and clumps of 30 to 40 bacilli were not unusual, especially in cases of acute miliary tuberculosis." From his observations he formulated the conclusion, "It appears that tuberculosis in all its forms is
SCHROEDER EC, COTTON WE. TESTS CONCERNING TUBERCLE BACILLI IN THE CIRCULATING BLOOD. Arch Intern Med (Chic). 1909;IV(2):133–149. doi:10.1001/archinte.1909.00050180035004
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.