In view of the rather extensive discussion as to the origin of the socalled malignant hypernephromas of the kidney, it is strange that practically no attempt seems to have been made to determine whether adrenalin-like substances are present in these tumors. Investigation of most of the literature on hypernephromas fails to show any instances in which the presence of blood-pressure-raising substances has been sought, although a few authors call attention to the existence of a marked arteriosclerosis in patients dying of hypernephroma, and suggest that this arteriosclerosis may be the result of a flooding of the blood with excessive quantities of adrenalin. A case of this kind is described by F. J. Hall1 in which a patient, aged 56, with a hypernephroma of long duration, showed a most extensive calcareous infiltration of the arteries throughout the body. On the other hand, von Hansemann2 reports
GREER JR, WELLS HG. THE ABSENCE OF ADRENALIN IN MALIGNANT RENAL HYPERNEPHROMAS. Arch Intern Med (Chic). 1909;IV(3):291–295. doi:10.1001/archinte.1909.00050190100007
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