The nitrogenous metabolism of typhoid fever has rarely been the subject of systematic study. It has long been known that this disease, rather more than other continued fevers, is marked by a very high urinary nitrogen excretion, but the partition of this nitrogen and the bearing of variations in the forms of nitrogenous compounds excreted in the urine on the pathology of the disease has received very scant attention. The reason for this paucity of effort lies, not in any supposed lack of importance in the subject, but in the fact that until recently there have been no satisfactory methods for the estimation of the different forms of urinary nitrogen, and no normal standards of comparison. Since both of these deficiencies have recently been met and partly removed there would seem to be opportunity for obtaining more significant results than have yet been secured in this
EWING J, WOLF CGL. THE CLINICAL SIGNIFICANCE OF THE URINARY NITROGEN: III. NITROGENOUS METABOLISM IN TYPHOID FEVER. Arch Intern Med (Chic). 1909;IV(4):330–355. doi:10.1001/archinte.1909.00050200036004
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