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Article
October 1909

THE MUCH-HOLZMANN SERUM REACTION IN INSANITY

Author Affiliations

KINGS PARK, N. Y.

Arch Intern Med (Chic). 1909;IV(4):405-408. doi:10.1001/archinte.1909.00050200111007
Abstract

While the present trend in psychiatry seems to be mainly in the direction of psychogenic causes in the etiology of the so-called functional insanities, yet from time to time cases are reported or in other ways facts are brought to light which would indicate that the toxic theory of the origin of these conditions is, at least for the present, not to be definitely discarded.

In a brief preliminary communication published a short time ago1 H. Much describes a new serum reaction which he found to be almost specific for dementia præcox and manic-depressive insanity. This reaction is based on the alleged power possessed by the serum in cases of these conditions of inhibiting the hemolytic action of cobra venom on human red blood corpuscles.

With the collaboration of W. Holzmann he examined the blood in four hundred cases, including, on the one hand, various forms of

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