Throughout the course of our studies on the formation of goiter it has been our aim to collect all the data possible as to the incidence, kinds and nature of the thyroid changes in animals so that when human thyroid changes were taken up at least some fundamental conclusions could be available as a point of departure. Nevertheless, while the supplanting of indirect and accidental observations on man by the direct observations on animals is the modern and logical way of approaching a medical problem, proper regard must always be had for the difference arising out of the different positions of the different animals in the biological scale of animal life, even though evidence is fast accumulating that their pathology is quite as applicable to man as their physiology, considering their position in the biological scale. This method of approach is particularly desirable in the case of the
MARINE D, LENHART CH. RELATION OF IODIN TO THE STRUCTURE OF HUMAN THYROIDS: RELATION OF IODIN AND HISTOLOGIC STRUCTURE TO DISEASES IN GENERAL; TO EXOPHTHALMIC GOITER; TO CRETINISM AND MYXEDEMA. Arch Intern Med (Chic). 1909;IV(5):440–493. doi:10.1001/archinte.1909.00050210033003
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