Hexamethylenamin, or, as it is commonly called, urotropin, was first prepared in 1860 by Butlerow.1 It is made by the action of ammonia on formaldehyd. It is readily broken up by heat, some acids, etc., into formaldehyd and ammonia. Nicolaier2 first introduced this drug into medicine in 1894. He concluded that it stimulated the secretion of urine, prevented the growth of bacteria in the urine, and acted as a solvent of uric acid calculi. In some cases he gave as much as 150 grains in a day without producing symptoms. On the other hand, smaller doses after prolonged use would occasionally cause burning in the region of the bladder, and the appearance of epithelial cells in the urine. If the drug was still continued red blood corpuscles would appear in the urine. As a result of these observations many men began to employ this drug. Casper3 and
FROTHINGHAM C. THE EFFECT OF HEXAMETHYLENAMIN ON GUINEA-PIGS. Arch Intern Med (Chic). 1909;IV(5):510–515. doi:10.1001/archinte.1909.00050210105006
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