Last year, in a paper read before this society, I proposed that the terms "blackwater fever," etc., be abandoned, and that the fever more or less closely connected with malaria and accompanied by hemoglobinuria should be divided into two groups, "pernicious malaria with hemoglobinuria" and "erythrolytic hemoglobinuria," the latter being the type most commonly meant by the old terms. I reported eight successive cases of pernicious malaria in which hemoglobinuria was demonstrated by the guaiac and turpentine test. The degree of hemoglobinuria varied from a mere trace, demonstrable only by the special test, to the intensity of black-water in two cases.
It was my idea then that the mechanism of the production of hemoglobinuria in the two types differed. I thought that in the first type the preceding hemoglobinemia was brought about by the destruction of innumerable erythrocytes, each by its infecting parasite, the unused hemoglobin being set
BREM WV. STUDIES OF MALARIA IN PANAMA: III. THE ETIOLOGY OF THE ERYTHROLYTIC HEMOGLOBINURIC TYPE OF BLACKWATER FEVER: A PRELIMINARY REPORT. Arch Intern Med (Chic). 1912;IX(2):129–136. doi:10.1001/archinte.1912.00060140003001
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