It is generally conceded that patients with acromegaly very frequently show either a transitory or a permanent glycosuria. Borchardt,1 in reviewing the literature of acromegaly, reports that when an examination of the urine is mentioned 35.5 per cent, of the cases show a glycosuria and an additional 5 per cent, a lessened sugar tolerance. Inasmuch as the glycosuria is often transitory and not infrequently independent of the character of the diet, unless the urine is repeatedly examined it may be overlooked. The presence of the glycosuria might be accounted for either on the one hand by pressure of the enlarged anterior lobe on the hypothetical sugar center or on the adjacent posterior lobe of the hypophysis, or on the other by the action of the hypophyseal secretion on sugar metabolism, either directly or through its correlated action with the thyroid or suprarenals. It has been noted
MILLER JL, LEWIS D. THE FREQUENCY OF EXPERIMENTAL GLYCOSURIA FOLLOWING INJECTIONS OF EXTRACTS OF THE HYPOPHYSIS. Arch Intern Med (Chic). 1912;IX(5):601–604. doi:10.1001/archinte.1912.00060170078005
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