The occurrence of perforating ulcer of the foot with certain disorders of the nervous system has long been recognized. The first description was given by Nélation in 1852. Since that time the condition has been described in connection with a number of nervous conditions. It is frequent in diseases of the spinal cord, such as tabes and syringomyelia, and has been noted in spina bifida, diseases of the conus medullaris, diabetes and alcoholism. Injuries to the sciatic and tibial, as well as tumors and local inflammatory disturbances of these nerves, have also caused this condition. It is frequent in the neuritis of leprosy. Its occurrence in multiple neuritis, aside from the form due to diabetes, is very infrequent. In the accessible literature I have not been able to find any record of its occurrence in alcoholic neuritis. Sonnenburg noted it in an alcoholic with anesthesia of the foot. Remak
VAN WART RM. PERFORATING ULCER OF THE FOOT IN ALCOHOLIC NEURITIS: REPORT OF A CASE. Arch Intern Med (Chic). 1910;V(4):371–373. doi:10.1001/archinte.1910.00050260048004
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