Following Richard Bright's observation, in 1827, of the direct association of albuminuria with pathological changes in the kidneys, the medical profession showed a natural tendency to regard the presence of albumin in the urine as a positive sign of nephritis. It was not long after Bright's discovery, however, that cases began to appear in which examination of the urine showed albumin to be present without any evidences of ill health in the patient and without the fatal outcome commonly associated with nephritis. Such observations have steadily increased in number, so that for some time past there has been an increasing tendency toward the belief that albumin in the urine is not necessarily an indication of serious pathological change in the kidney.
This tendency to regard the presence of albumin as of not very serious moment has led to the adoption of numerous terms to define the
HOOKER DR. POSTURAL OR ORTHOSTATIC ALBUMINURIA: A CRITICAL SUMMARY OF THE LITERATURE. Arch Intern Med (Chic). 1910;V(5):491–509. doi:10.1001/archinte.1910.00050270045005
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