The following observations were thought to be of value because they add to the number of reported cases of a somewhat rare disease and because I believe that they throw some light on an obscure and much-discussed subject. The report of a case of Hodgkin's disease running an acute course, the diagnosis of two other cases by the examination of lymph-nodes removed surgically, the report of a case of tuberculous lymphadenitis whose histologic appearance closely simulated that of Hodgkin's disease, and a case of Hodgkin's disease that appears to have undergone sarcomatous transformation, form a series from which, with other observations from the literature, certain well-supported conclusions may be drawn.
I shall not go into a wearying presentation of the literature, which has been reviewed most completely in the papers by Reed,1 Longcope,2 and Yamasaki,3 and in some of the more extensive articles such as those