Early in 1909 Noguchi1 brought to the attention of the medical profession a modification of the Wassermann system of complement fixation test for syphilis. It was in reality a new system for the detection of the so-called syphilitic antibodies, based on the Bordet-Gengou2 phenomenon of complement fixation, as in the Wassermann method, but using an antihuman hemolytic system as indicator instead of the antisheep system of the original method. Although differing from the latter in technical application, this variation in the hemolytic indicator represents the fundamental difference between the two systems.
Noguchi claimed for his method simplicity, greater facility of application, greater sensitiveness in the detection of the specific reacting bodies, and the possibility of so preparing the various reagents used in the test as to make it available for every laboratory worker or physician familiar with clinical laboratory methods.
A glance at Noguchi's
KALISKI DJ. SPECIFICITY OF THE NOGUCHI MODIFICATION OF THE WASSERMANN REACTION. Arch Intern Med (Chic). 1910;VI(2):205–217. doi:10.1001/archinte.1910.00050300086007
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