Our knowledge relating to the function of the corpus luteum is limited to a few isolated and disjointed facts. The minority are based on reliable experimental data ; the majority are insecurely founded on clinical observations, which permit of widely differing interpretation.Even a cursory study of the corpus luteum under the microscope will convince an unbiased observer that a structure which is stamped with all the hallmarks of an extremely active gland must possess at least some, and probably important functions.As Fraenkel has shown, the corpus luteum is widely distributed in the mammalian series. It should be classed among the glands of internal secretion, enjoying the unique distinction of being transitory, appearing with each cycle of rut or menstruation, and persisting during the major part of gestation.The voluminous literature dealing with the corpus luteum is readily accessible.1 In this connection only the following articles need
FRANK RT. HAS OVOTHERAPY, AS NOW PRACTICED, AN EXPERIMENTAL BASIS ?. Arch Intern Med (Chic). 1910;VI(3):314–329. doi:10.1001/archinte.1910.00050310085008
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