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October 1910


Arch Intern Med (Chic). 1910;VI(4):339-379. doi:10.1001/archinte.1910.00050320002001

INTRODUCTION  Some years ago, following a suggestion made by Dr. W. S. Thayer, I undertook to study the condition of the heart muscle of patients who had died of typhoid fever in the Johns Hopkins Hospital. It has long been a custom in the pathological department to save portions of the organs from all autopsies. Such portions have been hardened in Müller's or Zenker's fluid and preserved in alcohol. With the consent of Dr. Welch this material was placed at my disposal. From the autopsy records I selected for study fifty consecutive cases of death during typhoid fever. In seven instances no heart muscle had been preserved, so that the number to be studied was reduced to forty-three. The portion of the heart muscle found consisted of one or more strips from the left ventricle. From various portions of these strips, small blocks were cut and imbedded in celloidin

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