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No other branch of medical science owes its progress to so uniformly divided a participation by physiologist, pathologist, and clinician, as does this ever-fascinating subject of the internal secretions. We may, indeed, venture the suggestion that perhaps one of the most valuable achievements made in this field is that it has served to bring together these interests, which tend always, to their very great detriment, to drift apart. Although each of the many subdivisions of the field has been the subject of monographic treatment, yet a thorough and extensive review of the entire ground has not previously been available, although the evident interrelationship of all the internal secretions indicates that only such a correlated review can be adequate. Professor Biedl, who has been an active investigator of various problems concerning internal secretions, has succeeded in the colossal task of meeting this need in our literature, in a manner which