The recent publications of Meyer,1 Schloss,2 Friberger,3 and others have brought non-bacterial fevers again into the foreground. Numerous articles have appeared from the clinic of Finkelstein, which have shown that sugar and various salts given hypodermically or by mouth produce fever in young infants suffering from the acute gastro-intestinal disturbance called dyspepsia. In 1907 Schaps4 showed that, by the hypodermic injection of even so small an amount as 5 c.c. of physiological salt solution, a febrile temperature could be produced. Although these observations were denied by Weiland5 they have since been substantiated by a number of observers. Meyer and Rietschel6 showed that in about 40 per cent. of the cases which reacted to physiological salt solution, no reaction could be obtained by the injection of the same amount of a modified Ringer's solution. These were not the first experiments, however, on
HELMHOLZ HF. PYROGENIC ACTION OF SALT SOLUTIONS IN RABBITS. Arch Intern Med (Chic). 1911;VII(4):468–478. doi:10.1001/archinte.1911.00060040029002
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