For some time now the conception of an acid intoxication has been familiar to every student and practitioner of medicine. Since the first work of Naunyn on this subject in which many of the pathological phenomena of diabetes were explained by the demonstration of an acid intoxication to which the name ``acidosis'' was given, a great many facts have been collected and which support in all essentials the original investigations of Naunyn and his pupils. And it has become more and more evident that disturbances, both quantitative and qualitative, in the ability of the body to deal with varying amounts of acid, are not only important but by no means infrequent occurrences. Contrary to the assumptión of the early investigators, whose views are to some extent maintained by many at the present time, it may be stated as a demonstrated fact that the reaction of the blood,
ADLER HM, BLAKE G. THE RETENTION OF ALKALI BY THE KIDNEY WITH SPECIAL REFERENCE TO ACIDOSIS. Arch Intern Med (Chic). 1911;VII(4):479–490. doi:10.1001/archinte.1911.00060040040003
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