Several isolated observations have been made in connection with the effects of internal secretions on malignant tumors. Thus Cahen1 records cases of carcinoma of the breast in which after an incomplete breast amputation, the ovaries, too, were taken out. Of these cases he reports in some, a total disappearance of axillary nodes with gain in weight, the best results being obtained in young women, while the operation was valueless in women over 49 years of age. The significance of such absence of germ glands is somewhat diminished by the observations of Stickler,2 who reports 200 cases of tumors in bovines, 100 of which were in castrated animals; and 120 tumors in equines, ninety-one of which were in castrated animals. In connection with other secretions Gwyer3 has administered the thymus gland in cases of tumor and reports decrease in rate of growth, decrease in pain, decrease and in
ROHDENBURG GL, BULLOCK FD, JOHNSTON PJ. THE EFFECTS OF CERTAIN INTERNAL SECRETIONS ON MALIGNANT TUMORS. Arch Intern Med (Chic). 1911;VII(4):491–499. doi:10.1001/archinte.1911.00060040052004
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