Meningococcus septicemia was first reported by Gwyn1 in 1899. The case was one of epidemic meningitis complicated by acute arthritis. The meningococcus was isolated from the spinal fluid, synovial fluid, and the blood. Cochez and Lemaire2 in 1901 were able to demonstrate the meningococcus in the blood of two meningitis patients. Jakobitz,3 Martini and Rohde,4 Lenhartz,5 Marcovitch,6 Robinson,7 and Duval8 have since made similar reports, the septicemia in all these cases being associated with meningitis. Elser,9 examining the blood in forty-one cases of cerebrospinal meningitis, found the meningococcus in ten, or about 25 per cent. It has been observed that in most instances where the meningococcus has been found in the circulating blood, the disease has been fatal, and some form of extrameningeal lesion has been present. The endothelial-lined cavities, such as the joints, pleura, pericardium and endocardium have been the sites of these complicating
CECIL RL, SOPER WB. MENINGOCOCCUS ENDOCARDITIS, WITH SEPTICEMIAITS BEARING ON THE MODE OF INFECTION IN EPIDEMIC CEREBROSPINAL MENINGITIS. Arch Intern Med (Chic). 1911;VIII(1):1–16. doi:10.1001/archinte.1911.00060070006001
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