It is quite generally conceded that a favorable sequel following the administration of a drug is not a satisfactory test of its efficacy in checking hemoptysis, for it has been proved clinically and experimentally that hemorrhages from the pulmonary vessels often cease with the most surprising promptness. This spontaneous cessation is occasioned through the relatively low pressure reigning in the pulmonary circuit, and the reticular nature of the lung parenchyma, which acts to hasten the clot formation. So efficient are these forces that, in the dog, it has proved impossible to produce a fatal result, even when the main branch to a lobe was cut. Unfortunately, the clinical evidence of fatal issues from hemoptysis indicates that man does not enjoy so certain a protection as the lower animals, a fact to be explained by the slower coagulation of human blood. Hence, the management of pulmonary hemorrhage
WIGGERS CJ. A PHYSIOLOGICAL INVESTIGATION OF THE TREATMENT IN HEMOPTYSIS. Arch Intern Med (Chic). 1911;VIII(1):17–38. doi:10.1001/archinte.1911.00060070022002
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