The object of this study has been to find whether, during the course of the different acute infectious diseases, any general lesion can be found in the arterial system which seems surely to be the result of the toxins of the disease or of a wide-spread distribution of the infective agent. Furthermore, if such a lesion does exist, is it of a kind that will result on healing in a permanent injury to the arterial system ?
That the infective agent may lodge locally in the arterial wall has been shown by the reports of cases in which the tubercle bacilli and the spirochetes of syphilis have been found in human arteries. Wooley1 has recently reported a case and refers to the other cases reported in which the tubercle bacilli have invaded the intima of the aorta in one or more places from the blood stream. Wright2 and Richardson
FROTHINGHAM C. THE RELATION BETWEEN ACUTE INFECTIOUS DISEASES AND ARTERIAL LESIONS. Arch Intern Med (Chic). 1911;VIII(2):153–162. doi:10.1001/archinte.1911.00060080033004
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