In 1910 Dr. Nathan E. Brill1 published a clinical study based on 221 cases of a disease which he has observed during the last fourteen years in the wards of Mount Sinai Hospital. His definition of the disease in question is as follows: An acute, infectious disease of unknown origin and pathology, characterized by a short incubation period (four to five days), a period of continuous fever, accompanied by intense headache, apathy and prostration, a profuse and extensive erythematous maculopapular eruption; all of about two weeks' duration, whereupon the fever abruptly ceases either by crisis within a few hours or by a rapid lysis within three days, when all symptoms disappear.
Although these cases have been taken for typhoid fever by the greater number of New York physicians, yet there is no question that Brill is right in emphatically stating that this is an incorrect interpretation of the
FRIEDMAN GA. BRILL'S SYMPTOM-COMPLEX; TYPHUS FEVER; MANCHURIAN TYPHUS. Arch Intern Med (Chic). 1911;VIII(4):427–439. doi:10.1001/archinte.1911.00060100012002
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